Senior Scientist, Screening & Compound Profiling

Job Description

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.

The Screening & Compound Profiling group at our Research Laboratories site in Rahway, NJ is looking for a highly motivated, talented and innovative Senior Scientist with a strong background in biochemical and cell-based assays to participate on cross-functional teams and drive drug discovery programs across multiple therapeutic areas. Successful individuals will use cutting-edge technologies to access unparalleled synthetically accessible chemical diversity. Scientists will be immersed in a multi-disciplinary environment (collaborating with Quantitative Biosciences, Data, AI & Genome Sciences (DAGS), Discovery Chemistry, Computational Structural Chemistry and project team colleagues) charged with progressing hits using detailed biochemical and cellular mechanistic profiling paired with informatics and high-throughput experimentation. Output from such work will enable drug discovery programs across oncology, immunology, neuroscience, cardiometabolic and infectious disease.

Key Responsibilities:

• Design, plan and execute robust scientific research activities utilizing biochemical & cell-based assays ‘at-scale’ to accelerate lead discovery.

• Represent Screening & Compound Profiling on cross-functional project teams influencing strategic direction with data/progress updates & insight.

• Contribute to a high-performance culture of inclusion, collaboration, engagement and self-accountability.

Education:

• PhD with 0-3 years of experience, Master's Degree with 3-6 years of experience or a Bachelor's Degree with >10 years of experience in assay development and high throughput screening, with the ability to succeed in a collaborative, highly matrixed environment

Required Skills & Experience:

• Experience in the development of cell and biochemical assays for pharmacological profiling and incorporating liquid handlers and detectors to support small molecule and peptide screening

• Demonstrated ability to work under tight timelines and independently execute experimental tasks.

• Guidance of scientific operations, strategy, and communication with a track record of collaboration on multidisciplinary teams in one or more therapeutic area(s).

• Interaction with therapeutic areas and chemistry across high-throughput screening, hit-to-lead and/or lead optimization discovery space.

• Passion for fostering a diverse and inclusive culture and contributing to the growth and success of colleagues.

• Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.

• Strong external reputation as evidenced through publications, presentations, and/or scientific community engagement.

Preferred Skills and Experience:

• Application of laboratory automation to biochemical and cell-based assay systems in both walk-up and integrated platform scenarios.

• Collaboration to identify, …