Senior Scientist - Discovery Oncology

Job Description

Job Description

We are seeking a highly motivated Senior Scientist to join the Discovery Oncology group. This is a lab-based position at our South San Francisco site. The ideal candidate must possess strong scientific knowledge and technical skills. They will be responsible for supporting and leading research projects focused on developing cancer therapeutics. The ideal candidate should work independently and excel in a collaborative team environment. Daily responsibilities include developing and optimizing assays, designing and executing well-controlled experiments, analyzing data, interpreting results, troubleshooting arising issues, and generating actionable insights to help drive project decision-making. The Senior Scientist will present progress updates at internal team and departmental meetings and will contribute to multiple projects simultaneously.

Education Minimum Requirements:

• Ph.D. degree with 0-2 years of postdoctoral experience, preferably in cancer biology, pharmacology, immunology, molecular biology, biochemistry, or related field or M.S. degree with 4+ years of experience in the biotech/pharmaceutical Industry, or B.S. degree with 7+ years of experience in the biotech/pharmaceutical Industry.

Required Experience and Skills:

• Experience developing research projects, ideally demonstrated by publications, presentations, abstracts, and/or work in the industry

• Cell culture and cell-based assays, including isolation and handling of primary human cells and tissues (e.g. PBMC, tumors)

• Multi-color flow cytometry, cell viability assays, cell line engineering (e.g., CRISPR, RNAi, target over-expression), ELISA

• Data analysis with a sound understanding of statistical concepts and software such as GraphPad Prism and FlowJo

• Strong oral and written communication and presentation skills

Preferred Experience & Skills:

• Ability to collaborate with in vivo pharmacology scientists to support endpoint sample analysis is highly desirable

• Technical expertise in the following areas is considered a plus: cell sorting, western blotting, imaging techniques, cell signaling, biochemical assays

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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace.  All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected US salary range:

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

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