Senior Specialist, Infectious Disease and Vaccines, Quantitative Pharmacology and Pharmacometrics (Hybrid)

Job Description

Senior Specialists in the Infectious Disease and Vaccines group in the department of Quantitative Pharmacology and Pharmacometrics (QP2) apply quantitative approaches to enable drug-development decision-making from post-Preclinical Candidate (PCC) to worldwide registration. Senior

Senior Specialists in QP2-IDVAX will work in collaborative teams with more experienced scientists across disciplines, and are expected to have or develop expertise in one or more areas necessary to perform the primary responsibilities of the role including:

• Applying quantitative approaches to develop and implement translational clinical pharmacokinetics and pharmacodynamics of new drug and vaccine candidates

• Developing and executing pharmacokinetics and pharmacodynamics modelling approaches, such as noncompartmental analysis, population pharmacokinetic, exposure-response, quantitative system pharmacology, viral dynamics modeling, model-based meta-analysis, and other model-based analyses.

• Perform clinical trial simulations to inform dose selection and go/no-go decisions

• Severs as a QP2 representative while being mentored by QP2 senior staff on drug and vaccine development teams to manage functional deliverables for assigned programs

• On the job, you will begin to develop a comprehensive understanding of global regulatory expectations of drug and vaccine development, including clinical trial design, clinical pharmacology, biomarker plans, and model-based drug development approaches. You will also develop leadership skills in areas such as mentoring, managing a program, project, or initiative. In addition to the responsibilities outlined above, Senior Specialists are expected to demonstrate good communication skills, collaborating within QP2-IDVAX and with other functional areas, as well as with external vendors and partners, creating an aligned, quantitative framework to impact decisions of drug development teams.

• The ideal candidate is collaborative, eager to learn and not intimidated by tough scientific challenges. Excellent communication skills both written and verbal are required including the ability to clearly present scientific data in cross functional group settings. 

• QP2 offers a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies.

Minimum required education:

• A Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at least two years of experience - OR- a MS or equivalent degree with at least four years of experience, where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia

• An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, or chemical/biomedical engineering.

Required experience and skills:

• Proficiency in R, NONMEM, Matlab, Python, or …