Senior Scientist, Cell Sciences Assays (Discovery Biologics)
USA - California - South San Francisco (Grand Ave)
Job Description
Our Company is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. our company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal to take our company's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
The Discovery Biologics Department is seeking a Senior Scientist to join the Cell Sciences team that leverages cell engineering and innovative bioassays to drive design and progression of biotherapeutics. Understanding cellular trafficking of large molecules is integral to Discovery Biologics and enables antibody discovery, functional characterization, and development of pipeline molecules. The Senior Scientist (R3) will be instrumental in monitoring the fate of various biologics modalities by assessing kinetics of internalization, recycling, endosomal escape, and functional activity to drive progression of our Discovery Biologics pipeline.
The successful candidate will possess a broad and strong technical background in cell biology, molecular biology, a range of cell-based assays as well as expertise in high content imaging technologies. This role will be based in South San Francisco and will work collaboratively with scientists and teams across our various our company's research sites.
We recognize that the diversity in our team is our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.
Key Responsibilities:
Antibody mediated receptor internalization and endocytosis
Familiarity with FcRn dependent cell-based recycling assays
Design, develop and execute bioassay methods that mimic the mechanism of action for biologic therapies
Assess and evaluate new technologies, suitable for bioassay development to enable mechanism of action studies and analytical characterization of molecular concepts
Explore next-generation reporters, proximity assays, and expression cassettes
Author associated method development reports, test procedures, and relevant method transfer documents
Contribute to and lead the authoring of patents and external publications
Present research findings at group meetings, project meetings, and at external meetings
Actively develop talent, strategically maximize diversity to complement and strengthen our team
Foster a high-performance culture of collaboration, engagement, self-accountability, and inclusion
Qualifications:
Education:
Bachelor's (with 7+ years), Master’s (with 4+ years) or Ph.D. in life sciences and relevant experience listed below
Required Experience and Skills:
Cell culture experience with a variety of human cell types including lymphoid & myeloid derived cell lines
Experience working with engineered cell lines to enable functional assays and mechanism of action studies
Expertise with FACS-based methods for characterizing cell surface expression
Proficient in monitoring antibody and receptor internalization with techniques like, imaging, Incucyte and FabZap
Experience in screening biologics using assays for cell killing, cell signaling, proliferation or reporter gene assays
Team player who can successfully work in cross-functional teams
Detail-oriented, highly organized, and able to multi-task with multiple projects
Strong oral and written communication skills
Preferred Experience and Skills:
Experience around Fc effector function and related assays
Knowledge of cell fractionation and organelle isolation for targeted protein degradation assays
Relevant experience with the development of biotherapeutics and general interest in functional characterization of large molecules
An innovator who proactively seeks opportunities to share their knowledge and enthusiasm
Worked with multiple vendors and contract research organizations to build on internal capabilities via outsourcing
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.
Expected US salary range:
$125,000.00 - $196,800.00Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
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RegularRelocation:
Domestic/InternationalVISA Sponsorship:
YesTravel Requirements:
No Travel RequiredFlexible Work Arrangements:
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11/30/2024*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
ApplyJob Profile
Hybrid Hybrid work Hybrid work model On-site Puerto Rico residents only Travel required US and Puerto Rico residents only
Benefits/PerksBonus eligibility Collaboration opportunities Diverse workplace Equal opportunity employer Flexible work Flexible work arrangements Healthcare High performance culture Hybrid work Hybrid work model Inclusion Inclusive environment Insurance Meetings Paid holidays Retirement benefits Separation benefits package Sick Days Vacation
Tasks- Assess new technologies
- Author method development reports
- Collaboration
- Communication
- Compliance
- Design and execute bioassays
- Develop talent
- Evaluate new technologies
- Foster collaboration
- Innovation
- Method development
- Present research
- Present research findings
Accountability Analytical Analytical Characterization Animal Health Animal Health Products Antibody Discovery Antibody internalization Bioassay development Biologic Biologics Biology Biopharmaceutical Biotherapeutics Cell-based assays Cell Biology Cell Culture Characterization Collaboration Communication Compliance Cross-functional Teams Design Development Diversity Diversity & Inclusion Education Endocytosis Engineering Expression FACS Fcrn recycling assays Healthcare High content imaging Imaging Inclusion Inclusive behaviors Innovation Life sciences Manufacturing Method development Molecular Biology Monitoring Organization Outsourcing Patent authoring Policy Proximity assays R R&D Research Research presentation Science Talent Acquisition Team Collaboration Teams Technical Vaccines Written communication
Experience4-7 years
EducationAnimal health AS Bachelor Bachelor's Biology Business Cell Biology Engineering Life Sciences Master Master's Molecular Biology Ph.D. Relevant experience Science
TimezonesAmerica/Anchorage America/Chicago America/Denver America/Los_Angeles America/New_York Pacific/Honolulu UTC-10 UTC-5 UTC-6 UTC-7 UTC-8 UTC-9