Senior Principal Scientist, Cell Line Development

Job Description

In April 2020, our Company announced plans to consolidate our New Jersey campuses into a single New Jersey headquarters location in Rahway, NJ in 2023 and 2024. Therefore, this role will be temporarily based in Kenilworth and exact timing of the departmental move to Rahway, NJ will be communicated at a future date.

Our Clinical Research and Pharmacovigilance team push the boundaries of global healthcare through research and innovation. Through clinical trials and surveillance, we ensure the safety and efficacy of our existing and pipeline products to produce safe, effective, innovative medicine.

Process Cell Sciences (PCS) is seeking a highly motivated and experienced Principal Scientist to help develop and characterize early and late stage mammalian commercial cell lines to support innovative biological pipeline projects.

Position Description:

The successful candidate should have industrial experience related to commercial CHO cell line development. Candidate must have an in-depth understanding of cell biology/molecular biology and hands-on experience of molecular techniques, mammalian culture and next-gene sequencing. Candidate should demonstrate and stay up to date on the knowledge in genomics, transcriptomics, proteomics and genome editing technologies. Candidate must have experience in executing complex study designs requiring highly organized data collection and management.

Primary Responsibilities:

• Serve as the subject matter expert in cell line development and technical lead to represent functional area for biologics pipeline programs

• Work independently, including proactive planning, trouble shooting and successful execution of complex experimental protocols for cell line development and technology assessment

• Complete and effectively manage multiple projects within timelines ensuring that all tasks and responsibilities are carried out according to high scientific and ethical standards.

• Interface and collaborate with other functional teams in Discovery, Process development, Analytics, Operation, CRO/CMO outsourcing in the planning, execution, and technical troubleshooting.

• Responsible for technical reports and relevant sessions of IND and BLA filing.

• manage a team of 4-5 scientists, mentoring and guiding team members on the completion of portfolio and technology projects.

• Publications in peer-reviewed scientific journals and external/internal presentations are expected

Position Qualifications:

Education Minimum Requirement:

• PhD in Molecular Biology, Cell Biology, Genetics or related Biological Sciences with a minimum of 8 years of cell line development or related experience in industry

Required Experience and Skills:

• Experienced in developing commercial cell line development (CLD) for recombinant protein expression.

• Experienced in coordinate CLD responsibilities for pipeline project and ensure timely communication between CLD and other functional areas within CMC team.

• Excellent project leadership …