Senior Director, Translational Medicine (MD)

The Senior Director Translational Medicine will be responsible for design, execution and reporting of First in Human (FIH), Translational Medicine (TM) and Proof of Concept (POC) studies and will work closely with Discovery, Preclinical, Biomarker, Genomics, Bioanalytical and Global Clinical Development teams to ensure efficient and scientific execution of early phase trials as well as development and execution of biomarker plans as well as identification and utilization of emerging biomarker and translational tools, new technologies and scientific capabilities in support of Otsuka’s pipeline. The Senior Director TM works closely with Head of TM as well digital and diagnostics groups to support development of biomarkers throughout life cycle of Otsuka’s compounds. The Senior Director TM will represent TM at cross functional teams to identify, introduce, and evaluate discovery assets and ensures incorporation of translational tools in early phase programs. Senior Director TM will participate in the Early Development Team (EDT) or serve as chair of Research and Development team (RDT) and support transition of discovery compounds from preclinical stage to first in human and POC and provides input to strategy and commercial teams for asset and indication mapping. The Senior Director TM will represent the TM group in governance and development teams and will support activities related to direct reports in TM group.

Job Description

• Oversee identification and utilization of emerging Biomarker, Translational tools, new technologies and scientific capabilities in support of Otsuka’s pipeline.
• Partner with internal and external research organizations to expand and facilitate development of early phase and discovery phase compounds and Translational tools.
• Provide expert advice to internal and external stakeholders and interact with subject matter experts for early development and go/no go decisions.
• Provide expert advice to internal and external discovery teams as well as academic and early investment partners on incorporation of Translational tools and studies in early development, lead optimization and go/no go decisions.
• Collaborate with internal and external discovery teams as well as BD, MSRD on activities related to early phase target and asset identification.
• Support development of biomarker plans for each compound in alignment with functional head as well as collaboration with Biomarker, Genomics and Bioanalytical, Digital, and other functions for early go/no go decisions, patient stratification and dose selection.
• Propose, design, and execute FIH, Experimental Medicine, Translational Medicine or POC studies.
• Work in close collaboration with Strategy and Commercial teams to identify new modalities and targets and execute internal and external Translational …