Senior Bioinformatics Scientist

Invitae is a leading medical genetics company trusted by millions of patients and their providers to deliver timely genetic information using digital technology. We aim to provide accurate and actionable answers to strengthen medical decision-making for individuals and their families. Invitae's genetics experts apply a rigorous approach to data and research, serving as the foundation of their mission to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people.

Invitae is seeking Bioinformaticians to join our team. This role will be centered around creating workflows, tools and algorithms to complement assay/product development. The ideal candidate should be able to deconstruct a problem statement into components which can be resolved programmatically. Having a comprehensive grasp of genomics and next generation sequencing will be key to succeeding in this role. The candidate should be independent, well organized and collaborative with clear communication skills. In addition, the ability to frequently switch between tasks will be helpful. 

As necessary, but not as a primary role, the candidate will assist the Clinical team in ad-hoc analysis and research required to meet regulatory requirements. You will be responsible for scaling our pipelines as we work toward our goal of providing low-cost genetic answers to billions of people.

 

What you’ll do:

• Develop high-performance bioinformatics workflows that can accurately and reliably analyze large volumes of NGS data using Nextflow in a system agnostic manner
• Collaborate in a cross-disciplinary team by building, deploying, and maintaining software solutions compatible with distributed and/or containerized systems
• Designing APIs using industry best practices to streamline communication between various Invitae platforms
• Develop best practices for analysis of NGS data including optimization of parameters, resource utilization, and consensus approaches across various NGS applications
• Mentor team members in a wide range of bioinformatics algorithms and the utilized statistical/probabilistic techniques, including awareness of accuracy, efficiency, assumptions, and limitations. 
• Mentor budding engineers/scientists by participating in code review/analysis sessions
• Drive genetics assay method development in a cross-disciplinary setting by critically analyzing and deriving insights from experimental data (including NGS, arrays, and novel technologies) using open source NGS tools and building custom tools when needed
• Develop reproducible analysis for research and development purposes
• Review, understand, and stay in compliance with Invitae HIPAA Security policies and procedures
• Optionally, build and evaluate algorithms and statistical models to improve existing genetics applications within and beyond NGS technologies and create novel ones
• Optionally, maintain a visible profile in the Bioinformatics community through publications, conference presentations, and collaborations

What you’ll bring:  

• Typically requires a minimum of 8 years of related experience with a Bachelor’s degree; or 6 years and a Master’s degree; or a PhD with 3 years experience.
• Preference is a Masters with 8+ years experience or PhD with 5+ years experience in Bioinformatics or Computational Biology
• Fluent in R/Python, *nix, and SQL like DB technology for data analysis
• Working knowledge of variant detection algorithms and the underlying models
• Working knowledge of standard bioinformatic tools used in NGS pipelines
• Working knowledge of pipeline workflow engines: Nextflow, Snakemake
• Strong knowledge of Genomics and Molecular Biology
• Solid understanding of Illumina sequencing technologies and metrics
• Formal software development experience (preferred)
• Understanding of Cloud Computing (preferred)

This salary range is an estimate, and the actual salary may vary based on a wide range of factors, including your skills, qualifications, experience and location. This position is eligible for benefits including but not limited to medical, dental, vision, life insurance, disability coverage, flexible paid time off, Spring Health, Carrot Fertility, participation in a 401k with company match, ESPP, and many other additional voluntary benefits. Invitae also offers generous paid leave programs so you can spend time with your new child, recover from your own illness or care for a sick family member.USA National Pay Range$110,000—$137,500 USD

Please apply even if you don’t meet all of the “What you bring” requirements noted.  It’s rare that someone checks every single item, it’s ok, we encourage you to apply anyways.  

Join us!

At Invitae, we value diversity and provide equal employment opportunities (EEO) to all employees and applicants without regard to race, color, religion, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of the San Francisco Fair Chance Ordinance.

We truly believe a diverse workplace is crucial to our company's success and to better serve our diverse patients. Your input is especially valuable. We’d greatly appreciate it if you can take a quick moment to make your selection(s) below. Submissions will be anonymous.

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