Scientist, Translational PK/PD

Job Description

The department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) is seeking a curious and collaborative scientist for our growing Translational PK/PD organization. The Translational PK/PD Specialist is responsible for driving application of our modeling and simulation capabilities to enable earlier and more confident decision making around PK/PD, modality selection and dose prediction across all therapeutic areas for small molecule, peptide and protein therapeutics. Specialists are skilled modelers that achieve results by interacting with multi-disciplinary discovery teams and partners from other functions within our company.

The Translational PK/PD Specialist role will help to drive impact in the drug discovery and translational space by:

• Incorporating in vitro and in vivo data into systems models (PBPK and PK/PD) of drug disposition and pharmacology in support of translational and reverse translational efforts across multiple modalities and therapeutic areas

• Understanding the impact of drug disposition on novel disease biology and pharmacological response (PK/PD) to inform human PK and dose projections

• Closely collaborating with project teams and across the PDMB organization to develop modeling and simulation strategies to identify and optimize drug candidates

In addition to the responsibilities described above, Specialists demonstrate strong communication skills collaborating across PDMB and with other functional areas to create a quantitative model-informed approach to impact program strategies and decision making on drug discovery teams through the application of translational PK/PD, mechanistic and PBPK models.

Required:

• MS/PharmD or equivalent degree in a STEM discipline

• Experience in performing hands-on translational PK/PD modeling using standard modeling software (e.g., Phoenix, Berkeley Madonna, Monolix, Matlab, R)

• Expert skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics

Preferred:

• Proficiency in written and verbal communication and problem scoping and planning.

• Expertise in biologics/large molecule/protein therapeutics modeling

• Expertise in PBPK modeling

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace.  All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
 

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected US salary range:

$101,100.00 - $159,100.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Hybrid

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

N/A

Required Skills:

Business Intelligence (BI), Database Design, Data Engineering, Data Modeling, Data Science, Data Visualization, Machine Learning, Software Development, Stakeholder Relationship Management, Waterfall Project Management

Preferred Skills:

Job Posting End Date:

11/18/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

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