Scientist, mRNA Display Screening

Job Description

Scientist, mRNA Display Screening

Our Research Scientists are our Inventors. Our goal is to find novel and effective therapies by identifying and targeting steps in disease mechanisms or pathways that could be inhibited or enhanced. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthroughs. Within Screening and Compound Profiling (SCP) we leverage cutting edge methodologies and innovative thinking to discover small molecule and peptide drug leads. SCP is currently seeking an exceptional individual to join the mRNA Display Peptide Discovery group in Rahway, NJ

The successful candidate will be integral to a team that drives the execution and expansion of the mRNA Display platform to accelerate delivery of high-quality peptides for our Company's Discovery programs. Candidates should be highly motivated to work in a collaborative and multidisciplinary environment. S/he will have hands-on experience, in molecular biology techniques and next generation sequencing, preferably in the context of display screening technologies, such as mRNA Display, DEL or Phage Display. This individual will partner with others in furthering our screening efforts, by developing reagents and implementing innovative workflows for mRNA Display. They will also work closely with team members to ensure implementation of best practices. A mindset of innovation and continual technological improvement is important.

Primary Responsibilities: 

• Prepare, QC and validate mRNA-Display RNA, DNA and protein reagents  

• Preparation of mRNA Libraries and DNA templates for In-Vitro Transcription and Translation

• Operate automated liquid handler screening workflows (Tecan experience preferable)

• Draft, Maintain and Update SOPs, protocols and other documentation

• Partner with team members to identify opportunities for innovation (platform and workflow improvements e.g. using automation)

Education Minimum Requirements:

• B.Sc or Master's degree with 2+ years relevant industrial experience

Preferred Experience and Skills:

• Expertise in RNA biology with deep understanding of RNA biochemistry and biology

• Previous experience with biochemistry and RNA characterization

• Deep understanding of molecular biology, including Next Generation Sequencing (NGS) in relation to display screening technologies or protein engineering

• Excellence in simultaneously handling multiple priorities

• Ability to work in a fast-paced environment

• Highly organized, detail-oriented and excellence in multi-tasking

• Excellent organizational skills and time management

• Recording activities in ELN and databases

• Enthusiasm, self-motivation, flexibility, and readiness/ability to learn new methods are critical

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