Associate Principal Scientist, Mass Spectrometry

Job Description

Translational Molecular Biomarkers (TMB) is responsible for the development and execution of clinical biomarker assays across all therapeutic areas and all phases of clinical development at our Company Research laboratories. TMB laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.

The Mass Spectrometry group within the TMB organization is seeking a highly motivated candidate to join our team. The individual will play a critical role in the development and validation of Mass Spectrometry based assays that are deployed in support of clinical trials. The candidate for this Associate Principal Scientist position should have strong technical expertise in Liquid Chromatography and Mass Spectrometry and in the quantification of peptides and proteins from tissues, particularly formalin-fixed, paraffin-embedded (FFPE) pathology tissue specimens. The candidate should have a strong interest in lab-based assay development, validation, and sample analysis. In addition, the candidate should have interest to collaborate closely with out-sourcing partners on the scientific oversight of assays that support our pipeline.

The individual will have the following responsibilities:

• Develop and validate mass spectrometry-based assays within TMB for all therapeutic areas and all phases of clinical development.

• Focus on workflows and capabilities to develop mass spectrometry assays in tissue, particularly FFPE tissue.

• Assist in the transition of biomarker assays from Basic Research to Clinical by providing technical guidance on fit-for-purpose assay validation.

• Interface with scientists and physicians in early and late-stage clinical development to execute on biomarker strategies in clinical trials.

• Writing memos, final reports and publications summarizing data, and writing/updating lab SOPs.

• Serve as a subject matter expert in mass spectrometry-based assay development and validation, collaborating with project teams, biomarker leaders, clinical operations and regulatory affairs on the implementation of these assays in clinical trials.

Position Qualifications:

Education Minimum Requirement:  

• BA/MS/PhD in a life sciences discipline (Biochemistry, Immunology, Molecular Pathology, Cell Biology, etc.) or Chemistry. BA/BS+13 years; MS+8, PhD +3.

Required Experience and Skills:

• A minimum of 5 years post Ph.D. in a related discipline (e.g., analytical chemistry, biochemistry, etc.).

• A minimum of 2 years of hands-on direct experience in mass spectrometry-based assay development for proteins in tissues (this experience does not need to be post-graduate)

• Extensive experience and knowledge in Liquid Chromatography coupled with Mass Spectrometry for quantitative assessments of peptides and proteins.

• Significant experience in the handling of biofluids (Plasma, …